Capturing Autobiographical Memory Formation in People Moving Through Real-World Spaces Using Synchronized Wearables and Intracranial Recordings of EEG

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, eye tracking) synchronized with invasive neural recordings. Researchers will analyze these multimodal data streams to develop new analytic approaches for studying memory formation in naturalistic settings, with the long-term goal of informing neuromodulation-based memory enhancement treatments for individuals with memory disorders.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• 18 years of age or older

• healthy to minor cognitive impairment

Locations
United States
Utah
Clinical Neurosciences Center, University of Utah
RECRUITING
Salt Lake City
Contact Information
Primary
Alireza Kazemi, PhD
alireza.kazemi@utah.edu
5303040970
Time Frame
Start Date: 2025-01-30
Estimated Completion Date: 2028-03
Participants
Target number of participants: 50
Treatments
No_intervention: Neuroethical Assessment Group
Patients with epilepsy who have Neuropace RNS implants who will be surveyed about the neuroethics of real-world multi-modal recordings to assess their attitude toward research data sharing and confidentiality.
Experimental: Multi-Modal Recording System Assessment Group
Patients with epilepsy who have Neuropace RNS implants, and patients without epilepsy/RNS implants, who will participate in real-world navigation and autobiographical memory tasks in order to evaluate the reliability and signal quality of the multi-modal recording system.
Related Therapeutic Areas
Sponsors
Leads: University of Utah
Collaborators: University of California, San Diego, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), University of California, Los Angeles

This content was sourced from clinicaltrials.gov